Thomsen et al. (2001) [ 85] discuss these extreme modulations and suggest that whistles in killer whales serve a different function than in related dolphins.
Electrophysiology studies in non-human primates have shown tuning of individual neurons to different modulation rates and suggest a tendency for neurons in primary fields to prefer faster rates than neurons in field higher up the hierarchy (Bieser and Muller-Preuss, 1996; Liang et al., 2002): see also (Joris et al., 2004).
Together, these findings show that DNp09 neurons are a key element in the circuit mediating the speed modulation of freezing expression, and suggest that this modulation is not a result of locomotion induced changes in visual perception43,44.
They highlight a role for superficial layer 2/3 pyramidal cells of the mPFC in the modulation of depressive behaviors and suggest that the major depression evident in patients with Wolfram syndrome and carriers may occur in part due to hyperactivation of the HPA axis in response to stress.
Nonetheless, our findings reinforce preclinical and comparative studies of serotonergic modulations of response inhibition, and suggest that patients with more severe motor signs (UPDRS scores) and relatively preserved structural connectivity in frontostriatal networks (from diffusion-weighted imaging) could be stratified to receive citalopram in further clinical trials.
Together, these data demonstrate a role for RNA splicing homeostasis in dietary restriction longevity and suggest that modulation of specific spliceosome components may prolong healthy ageing.
Therefore, our results reveal a novel mechanism for morphological evolution and suggest that modulation of the expression of miRNAs potentially plays a prominent role in generating organismal diversity.
The above studies suggest that NR4A1 plays distinct roles depending on the cell context and signal stimulation, and suggest that modulation of NR4A1 activity may be used as an anticancer therapy.
These data demonstrate for the first time that EpCAM expression can influence the JNK/AP-1 signal transduction pathway, and suggest that modulation of AP-1 transcription factor activity contributes to EpCAM-dependent breast cancer invasion.
Our results indicate that acute inflammation stimulates the regenerative response in neonatal mouse heart, and suggest that modulation of inflammatory signals might have important implications in cardiac regenerative medicine.
