Thus, it may be that modulation of the function and maturation of infected DCs, rather than inhibition of antigen presentation per se, determines the relative importance of direct versus cross-priming of CD8+ T cells in MCMV infection.
Interactions of focal adhesion proteins with integrins are important for focal adhesion formation and maturation, modulation of integrin-ligand binding affinity and ECM remodeling [ 11, 12].
Falace, A. et al. TBC1D24 regulates neuronal migration and maturation through modulation of the ARF6-dependent pathway.
Combined, these results strongly suggest that the modulation of CTMP protein levels and maturation affect mitochondrial shape.
Regardless of this atypical mechanism, our data suggest that Musashi, and perhaps Hes1, contribute to the modulation of β-cell proliferation and maturation.
Finally, we discuss modulation of the MHCII presentation pathway across B cell development and maturation to effector cells, with an emphasis on the shaping of the MHCII/peptide repertoire by two key antigen presentation regulators in B cells: HLA-DM and HLA-DO.
Therefore, we hypothesized that CHBP may have the ability to promote anti-rejection via the modulation of innate immunity, particularly pathogen-associated molecular patterns-induced activation and maturation of DCs.
It has become increasingly clear that induction and modulation of T cell immunity against tumors require immunogenic formulations that allow efficient targeting and maturation of dendritic cells (DCs) [83], [84].
To determine whether dendritic cells (DCs), innate immune cells that specialize in initiation and modulation of immune responses, are present in ovarian follicular fluid (FF) and whether their abundance and maturation state correlate with ovarian response to gonadotropins.
Our results reveal that neuronal polarization and contact guidance are based on a geometrical constraint of focal adhesions resulting in an angular modulation of their maturation and persistence.
