Sentence examples for modulation activity of from inspiring English sources
This work explains the structural basis for the splicing modulation activity of PB and related compounds, and reveals key interactions between SF3B and a common pharmacophore, providing a framework for future structure-based drug design.
Given the convolution of hormone receptor functions in prostate cancer cells [18], it could only be presented as a working hypothesis that, similar to MCF-7 breast cancer cells [6], the observed growth stimulation of PC-3 and DU-145 cells by nanomolar concentrations of dihydro-R can be attributed to the hormone receptor modulation activity of this compound.
The apical membrane modulation activity of spastin was further confirmed by spastin overexpression which caused a dramatic expansion of the apical membrane domain (Figure 5).
This study investigated the effects of sustained release of ADM on the modulation activity of osteoblasts and vascular endothelial cells in vitro.
The actin modulation activity of the WxxxE effectors Map, IpgB1 and IpgB2 were previously shown to be dependent on their invariant WxxxE motif (Alto et al., 2006).
The in vivo gene modulation activity of CDIM9 was further investigated by immunoblotting analyses of MDA-MB231 xenograft tumor lysate after treatment with 64 mg/kg CDIM9 by intraperitoneal injection every day for seven total doses.
By using a combination of genomic and proteomic experimental approaches, we investigated the ex vivo effects of a candidate medicinal plant extract, [BF/S+L/Ep], on the differentiation and modulation activities of mouse BMDCs.
We predicted that this might correlate to modulation of activity of "global neuronal workspace" neurons and co-activated local processors in visual or auditory regions.
Modulation of activity of cellular kinases and, in particular, members of the ERK/MAPK family, occurs through transduction of extracellular signals [ 72, 73].
Of course, this does not rule out an additional role for non-transcriptional mechanisms in the modulation of activity of these factors.
Inhibition of this integrin-mediated effect of thyroid hormone decreases cellular pHi and may permit modulation of activity of enzymes whose pH optima are physiologic or slightly alkaline.
