Sentence examples for modulating transcription of from inspiring English sources

When synthesized in the nucleus by SphK2, S1P is reported to inhibit histone deacetylase 1 and 2 (HDAC 1/2) with the effect of modulating transcription of, for example, cyclin dependent inhibitor p21 and the transcriptional regulator c-fos.

Nuclear factor I (NFI) belongs to a family of transcription factors that play important roles in modulating transcription of differentiation-associated genes [44].

One way to explain the multifaceted nature of BRCA1 is that it exerts its many effects through modulating transcription of various factors.

Misexpression of Polycomb repressive complex 1 (PRcomponentsents in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene.

Recently, lncRNAs have also shown their tumorigenic potential by modulating transcription of p53 [ 24].

Retroelements may have a profound impact on the plasticity of the host genomes [ 49], i.e. modulating transcription of immediately downstream host genes [ 50, 51].

Activated JNK phosphorylates c-Jun, a nuclear transcription factor, to increase AP-1 transcriptional activity, which modulates transcription of a number of apoptosis genes such as FasL.

This suggests that the peptide may modulate transcription of the cyclins while affecting the stability of HPV16E7 and pRb protein.

EGR1 is a member of the immediate-early gene group of transcription factors which modulate transcription of multiple genes involved in cell proliferation, differentiation, and development.

These data suggested that one or more regulatory elements might modulate transcription of frataxin under varying metabolic conditions such as iron starvation.

c-Myc is a basic helix-loop helix transcription factor that directly modulates transcription of a large number of genes controlled by all three RNA polymerases [2], [3], [4].