Sentence examples for modulating transcription in from inspiring English sources

To understand transcriptional regulation of gene expression from the perspective of systems biology, rather than from the analysis of an individual regulatory protein, we compiled the current knowledge on the defined DNA-binding transcriptional regulators and their physiological role in modulating transcription in response to environmental signals.

In those ATF/CREB family members identified by our analysis, CRE-BP1/ATF2 has been implicated in transcriptional control of stress response genes [ 36]; CREB is involved in modulating transcription in response to intracellular cAMP concentrations [ 37] and ATF4 acts as negative regulator of cAMP responsive element (CRE)- dependent transcription [ 38].

This complex is important for modulating transcription in response to carbon source changes (Kim et al. 2012).

If TG2 inhibition acts independently of histone acetylation, how is TG2 then binding to chromatin and modulating transcription in the presence of mhtt?

It is speculated that AES functionally modulates transcription in the nucleus, but AES has also been shown to function in the cytosol [22].

To analyze whether the motifs identified by the Trawler pipeline were able to modulate transcription in a light dependent manner, oligonucleotides containing the concatemerized motifs separated by 10 bp spacers were subcloned into pLucMCS (Stratagene) upstream of the luciferase reporter gene as previously described ([17], see Table S6 for the oligonucleotide sequences).

However, we found that CCN3 was able to modulate transcription in other systems.

Since MBD proteins modulate gene expression, we tested the ability of Mbd5 to modulate transcription in an in vitro system.

The variable amino-terminal A/B domain harbors the constitutive activation function (AF -1, which modulAF -1transcription in a gene- and cell-specific manner.

DNA hairpin and cruciform structures are known to initiate replication and to modulate transcription in other species (Bikard et al. 2010; Brazda et al. 2011).

Therefore, using a Gal4 reporter system, we showed that nuclear CCN3 forms were able to modulate transcription in various eukaryotic cells.