Sentence examples for modulating their trafficking from inspiring English sources

Our results indicate that PLCγ2 is involved in actin cytoskeleton reorganization and Rac-activation in DCs thereby modulating their trafficking to the lymph nodes and their ability to interact with T cells.

Huntingtin is a large membrane-associated scaffolding protein that associates with endocytic and exocytic vesicles and modulates their trafficking along cytoskeletal tracks.

Thus, a decrease in the cell surface expression of CD1 molecules by blocking their synthesis, export to the cell surface or by modifying their endosomal trafficking will modulate their sampling activity and activation of NKT cells.

Ubiquitin (Ub) and ubiquitin-like proteins (Ubls) form a family of small and highly conserved post-translational modifiers that become linked to target proteins and thus modulate their function (such as degradation, trafficking and signalling).

Palmitoyltransferases make interesting drug targets for therapeutic intervention, mainly because of their involvement in the modification of oncoproteins [21] and their role in modulating neuronal trafficking and function [6], [7], [9].

Host Spns2 is demonstrated as an important metastatic promoter via modulating lymphocyte trafficking.

It participates in the immune reaction by modulating the trafficking of leukocytes, the maturation of epidermal DCs and the activation of T-cell in the antigen presentation (Mummert, 2005).

They found host Spns2 plays a role in promoting metastasis via modulating lymphocyte trafficking (Fig. 1), outlining Spns2 as a promising therapeutic target against tumor metastasis, which may take the place of existing S1P pathway interventions to overcome their broad side-effect.

Thus, calcium affects p65 (RelA)/NF-κB activity by modulating its trafficking into the nucleus.

Finally, in cultured cells, downregulation of UBQLN1 expression alters APP levels and Aβ secretion by modulating APP trafficking [49].

Such variances among NPC cases should therefore be taken into account when formulating therapeutic strategies aimed at modulating the trafficking of cholesterol or other sphingolipids.