SOCS3 has been shown to interact with molecules in metabolic pathways and modulate their signaling [ 19].
Based on new developments in the field, exciting opportunities for therapeutically targeting the meta-stable structural states of membrane-less organelles to modulate their signaling behavior are on the horizon.
Here we consider the importance of receptor interactions in modulating their signal output and how such interactions vary in the receptor family.
To this end, we consider the importance of receptor interactions in modulating their signal output and how such interactions vary in the receptor family.
Follistatin domain containing proteins have been shown to interact with growth factors or their binding partners and modulate their signaling [19], [24], [38].
Alternatively, in Drosophila, type IV collagens directly bind to bone morphogenetic proteins (BMPs), a class of TGFβ signaling molecules, and participate in morphogen gradients and modulate their signaling (67, 68).
uPAR participates in many cellular processes by interacting with β1 and β3 integrins and modulate their signaling, by serving as a binding site for VN and by inducing cytoskeletal reorganization [ 14, 30].
If fluorophore signals can be selectively modulated, their signals will shift away from the unmodulated background, drastically improving their visibility and signal-to-noise ratio (SNR).
These ECM molecules might interact with growth factors, chemokines or members of the Wnt family, or their receptors, to modulate their signalling [ 9].
Key players that are involved in cellular transformation and tumorigenesis are the AP-1 and NF-κB transcription factors; therefore, we assessed how β-tan and Sal A modulate their signaling pathways in JB6P + cells.
