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Microglia are extremely sensitive to even small pathological changes, eliciting prompt responses by modulating their number, morphology and cell surface receptors.
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Moreover we describe that iloprost infusion has a strong effect on endothelial cells and progenitors since it is able to modulate both their number and their gene expression profile.
We defined a gene-wise dosage effect score (DES) to identify genes whose copy number changes modulate their own expression.
They identified the gene copy number changes that modulated their own expressions and indirectly affected the expressions of their target genes.
This is because, in the absence of male harassment, females can maintain mating rates close to their reproductive optimum by modulating the number of matings with males accordingly.
The release kinetics of a therapeutic buried within a dendrimer carrier are tuned by modulating the number of generations or altering the surface chemistry.
We further optimized gene expression by modulating the number and placement of ZF-binding sites within the artificial promoter, which have been shown to be important parameters for maximizing the expression of regulated genes27.
Furthermore, they showed that the information transduction capacity of genes can be tuned in cis : modulating the number and location of Msn2 binding sites in the promoter can increase information transduction.
By suppressing AM cytokine gene expression PT may be modulating the number and function of other effector immune cells required for viral clearance and controlling lung inflammation.
Cell lysis, protein binding and washes were optimized by modulating the number of pipetting cycles, the shaking speed and the volumes of various reagents.
Furthermore, Scc17, modulating tumor number, and Scc21 were found to interact to affect tumor load.
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