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The idea to associate ATP to pharmaceutical formulations/biotechnological devices to promote cells activity by potentially modulating their microenvironment thus appears as an appealing novel approach.
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This observation supports the notion that tumour cells actively modulate their microenvironment, possibly by the expression of cytokines and chemokines.
Glioma cells in vitro and in situ express various ECM components that modulate their microenvironment and promote migration, including collagens, laminins, brevican, tenascin-C and SPARC.
The data do not yet distinguish whether functional or ontogenetic plasticity creates this phenotype, although they suggest that cells which give rise to hemangiosarcoma modulate their microenvironment to promote tumor growth and survival.
Although it is difficult to correlate heterogeneous ECM protein expression patterns in the same or among different tumours and migratory and invasive behaviour, the findings suggest that glioma cells are able to modulate their microenvironment thus affecting survival, migration and invasion.
Furthermore, there is a reciprocity between GSCs and their microenvironment: GSCs are capable of modulating their own microenvironment to produce signals to recruit other immature cells in the vicinity.
The existence of distinct DC subsets is due to their inherent plasticity and to the changing microenvironment modulating their immunological properties.
Cells undergoing apoptosis are known to modulate their tissue microenvironments.
This implies that HCC tumors can modulate their local and adjacent microenvironment, thus enabling better energy supply to fuel tumor growth.
Heterochronic parabiosis was shown to restore the regenerative potential of satellite cells, which suggests that satellite cell activity can be modulated by their microenvironment.
The basement membrane is not only important as a structural component supporting cell, but also gives to the cells an instructive microenvironment that modulates their function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com