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Cuticle protein genes were actively transcribed in B. mori wing at P0 stage, so HR38 might be involved in modulating their expression.
Moreover, proteasome inhibition with bortezomib alters the binding of other transcription factors to the promoter region of several molecular effectors, thus modulating their expression levels [ 149].
Mi(cro RNAs are short RNA molecules that bind (generally) to 3' UTR sequences of target messenger RNAs (mRNAs), thereby modulating their expression patterns.
These include three homologous and membrane associated arabinosyltransferases encoded by three contiguous genes, embC-embA-embB, isoniazid-inducible genes particularly iniA, acyl carrier proteins and regulatory proteins modulating their expression [ 11- 13].
Substantial induction of these defence, cellular signalling and metabolism genes by PPV and other positive sense RNA viruses in infected leaf tissues suggests that there is a shared pathway modulating their expression.
Based on the same principle, artificial transcription factors (ATFs) have been generated by fusing various functional domains to a DNA binding domain engineered to bind to the genes of interest, thereby modulating their expression.
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Ex-vivo glutamate administration on SCN brain slices induces robust increases in per1 and per2 expressions; however, micromolar concentrations of PACAP alone was unable to modulate their expression.
Since the recognition of these proteins, several attempts have been made to modulate their expression and activity (protein kinase C inhibitors, anti-MDR-1 oligonucleotides, pharmacological competitors and transcriptional inhibitors).
This, together with the result that EE leads to normal RGC dendritic stratification in DR mice, suggests that the factors EE acts upon to trigger the refinement of RGC circuitry do not require visual experience, although visual experience may modulate their expression.
Although other experiments are required to elucidate the role of the MarT and FidL proteins, it is tempting to speculate that they belong to the same group of transcriptional regulators that are encoded in mobile genetic elements and act on AT-rich sequences to modulate their expression in receptor bacteria.
Alternatively, FUS3 may act through ethylene synthesis or signaling to modulate their expression.
More suggestions(15)
modulating their dendritic
modulating their function
modulating their exercise
modulating their signaling
modulating their excitability
modulating their availability
modulating their fusion
modulating their differentiation
modulating their trafficking
modulating their tone
modulating their microenvironment
modulating their number
modulating their shape
modulating their action
modulating their rate
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