Sentence examples for modulating their activity from inspiring English sources

PARP1 binds hnRNPs4,44,45, modulating their activity, to alter splicing decision4,45.

Traditional drug discovery starts by experimentally screening chemical libraries to find hit compounds that bind to protein targets, modulating their activity.

These potent vectors offer new opportunities for characterizing the identity and connectivity of single neurons within immense networks and modulating their activity via robust delivery of functional genetic tools.

Although the natural ligands of class C receptors bind to their extracellular N-terminal domains, the possibility of modulating their activity through ligands that bind to their helical bundle has been reported.

For example, chemical gradients can be controlled by manipulating the micro-environment [18], [19], delivering growth factors or modulating their activity, such as overexpressing growth factors to level the gradient or saturate receptors or genes encoding inhibitory factors or dominant negative receptors [20].

Although the natural ligands of class C receptors bind to their N-terminal domains, a number of articles, in agreement with our results, have reported the possibility of allosterically modulating their activity through ligands that bind to the 7-TM cavity [70] [76].

It is not surprising that these enzymes became the focus of intense research as therapeutic potential of modulating their activities became apparent.

AA can bind to biological proteins modulating their activities.

Chl can bind to biological proteins modulating their activities.

Rho proteins, once activated, stimulate signalling in multiple pathways by binding to downstream effector proteins, modulating their activities and thereby regulating a range of cellular processes.

Additionally, other types of PTMs occurring on kinases as previously described play a role in modulating their activities, which are usually not accounted for in these studies.