Sentence examples for modulating the synthesis from inspiring English sources

This has led to intense interest in developing compounds capable of modulating the synthesis of steroid hormones.

Some studies suggested that σ1 receptor is involved in modulating the synthesis and release of dopamine and also to act as a molecular chaperone at the mitochondrion-associated endoplasmic reticulum membrane (MAM) where it regulates calcium signaling between the two organelles [4, 18 20].

It is thus important to characterize the mechanisms involved in the control of lipid absorption in these cells, especially those modulating the synthesis and secretion of TRL, as this could lead to the development of drugs acting on the early control steps in the intestinal transfer of dietary lipids, which could be used to reduce postprandial hypertriglyceridemia.

Moreover, in stressed β-cells mTORC1 inhibition decreases IRE1α protein expression and JNK activity without affecting ER protein load, suggesting that mTORC1 regulates the β-cell stress response to glucose and fatty acids by modulating the synthesis and activity of specific proteins involved in the execution of the ER stress response.

In summary, our data contradict the assumption that mTORC1 augments ER stress by increasing cell metabolism and protein synthesis and suggests instead that it regulates the β-cell stress response to glucose and fatty acids by modulating the synthesis and activity of specific proteins involved in the execution of the ER stress response, such as IRE1α.

Creating novel biosynthetic pathways and modulating the synthesis of important compounds are one of the hallmarks of synthetic biology.

Our goal was to investigate the ability of TGF beta 1 to modulate the synthesis and accumulation of decorin, biglycan, and fibromodulin in cartilage explants cultured under conditions in which aggrecan synthesis remains relatively constant.

In view of these results, we assessed the capacity of the different sHZ crystals, nHZ, rcHZ and scHZ, to modulate the synthesis of this important inflammatory mediator.

In a recent study in Salmonella, it was projected that Hfq modulated the synthesis of ∼20% of all proteins either directly or indirectly [19].

Inhibition of eIF4A selectively and simultaneously modulates the synthesis of proteins involved in Alzheimer's disease: reducing A-beta and tau synthesis, while increasing proteins predicted to be neuroprotective.

Recent studies in Saccharomyces cerevisiae, for example, have revealed mechanisms that modulate the synthesis of C-terminally extended proteins by regulating the efficiency of stop codon readthrough in response to cellular stress, a process that may impact on the ability of cells to respond and adapt to fluctuating environmental conditions (reviewed in [12]).