These reflect subthreshold membrane potentials and strongly modulate the spiking of hippocampal neurons and synchronise across the hippocampus in a travelling wave pattern.
Despite their crucial role in modulating the AIS spike-generating properties [ 12- 14], the developmental time course of expression of Kv1 channels at the AIS has to date never been studied.
One powerful means of controlling excitability is to directly modulate the site of spike initiation, the axon initial segment (AIS).
In conclusion, we propose that the regular patterns, which comprise the majority of spikes in PC SS trains, can control the amplitude of subsequent timing signals by modulating the amplitude of rebound spikes in downstream DCN neurons.
By investigating the CA3 PC rate-driven input output function of CA1 PC using in vitro electrophysiology, in vitro-simulation of inhibitory network, and in silico computational modeling, we demonstrated for the first time that GABAA receptor-mediated FF and FB inhibition differentially modulate the gain, the spike precision, the neural code transformation and the information capacity of CA1 PC.
b Spike time shifting: Independent noise leads to shifting of spikes by weakly modulating the integrand in Eq. (16) independently for both neurons, but no spikes are added or deleted.
a Addition and deletion of spikes: Independent noise processes lead to addition and deletion of spikes by weakly modulating the threshold value in Eq. (11) independently for both neurons.
The canvas grins through, modulating the whiteness.
Indeed, in animals it is meanwhile well established that theta phase can modulate the stimulus-specific spiking of neural ensembles in many different brain regions, such as the hippocampus, visual cortex, and prefrontal cortex [ 9 13].
While single cell rate and phase tuning curves in this coordinated assembly model are identical to those in the independent coding model, a peer weight function also modulates the probability of a spike occurring in each cell depending on the spikes of its peers.
