Sentence examples for modulating the site from inspiring English sources

Although inflammatory proteins were not assessed in this study, our data along with the aforementioned studies [ 155, 156] suggest that a rise in IL-1β activity and/or the activity of its primary transcription factor NF-кB may be involved in modulating the site specific effects of 11β-HSD1 and/or glucocorticoids on preadipocyte differentiation and adipocyte metabolism.

One powerful means of controlling excitability is to directly modulate the site of spike initiation, the axon initial segment (AIS).

The distinction between residues that are directly involved in catalysis through, for instance, nucleophilic attack or proton transfer (such as D105 and H300) and those that act by electrostatically modulating the active site is proving to be subtle.

We observed that HIPS conjugation produces physiologically stable conjugates; however, modulating the conjugation site had a pronounced effect on antibody efficacy and PK, and resulted in ADCs with an improved safety profile as compared to a conventional lysine-conjugated ADC.

In summary, the above experimental results suggest that the pZBD in GluRS not only affects the local interaction with tRNAGlu acceptor arm (thus modulating the active site) but also affects the catalytic step of glutamylation reaction indicating some distant communication with other part of the protein.

Thus, expression of IL-10 from Th1-conditoned cells may contribute to maintaining the cells in an effective state in vivo rather than directly modulating the lesion sites.

It is known that pathogenic mutations near the C-terminus of the Aβ sequence in APP can lead to increased generation of Aβ42 by modulating the active sites of γ-secretase.

We have also reinforced the evidence in support for a role of RNA binding by AID in modulating the preferred sites of mutation by the addition of new genetic data, ChIP data and expression analysis.

These results show that a highly pathogenic avian influenza virus can be attenuated by modulating the caspase cleavage sites of NP and M2 and that these sites should be considered as novel targets for the design of live vaccines.

These findings showed that cytochalasin B inhibited glucose uptake and transport by modulating the active binding sites of GLUTs and not by degrading the actual GLUTs protein contents.

This type of binding may induce a conformational change in the acyl pocket loop which modulates the catalytic site via a domino effect.