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Consistent with the findings of previous studies, our results confirm the functional role of ORAI1 polymorphism rs12313273 in modulating the serum calcium concentration.
In a time-course study to evaluate the specific effect of peptide in modulating the serum sPLA2 levels in Tg197 mice (Fig. 8), P-NT.II significantly suppressed the circulating sPLA2 in the mice at age 8 weeks (P < 0.05), by comparison with the serum levels of the untreated mice of same age.
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The development of novel drugs designed to modulate the serum levels and functionality of HDL particles should also continue.
To test the hypothesis that these phenolics can modulate the serum and very low-density lipoprotein (VLDL) triacylglycerol concentrations in humans, a double-blind, randomized, crossover trial was designed.
Besides, they modulate the serum levels of some collagen type-II molecular biomarkers [ 22] as well as some proteolytic enzymes, such as metalloproteinases [ 23].
To determine whether RhoA and Rac1 modulate the serum deprivation-dependent upregulation of the NHE1 via this same mechanism, we analyzed the effect of the dominant negative mutants of RhoA or Rac1 on the dependence of NHE1 activity on pHi in serum deprived cells, as previously described [ 6].
Similar to our results, Naicker et al. [ 22] found that genotype -592AA (low levels) was associated with a greater magnitude of response from virus-specific CD8+ T lymphocytes, suggesting that allelic variants can influence the rate of disease progression by regulating serum levels and modulating the immune response by cytotoxic lymphocytes.
This may be due to alterations in serum lipid metabolism during sepsis, modulating the host response to inflammation in critically ill patients.
Serum contains proteins that may produce lung injury directly by affecting endothelial cells and indirectly by modulating the effects of endotoxin (lipopolysaccharide).
The canvas grins through, modulating the whiteness.
Krill oil did not modulate the levels of serum cytokines whereas consumption of fish oil increased the levels of IL-1α and IL-13.
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