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Several studies indicate that activation of the AT2R has effects that oppose those mediated by the AT1R, thus modulating the responses to stimulation with Ang II.
In addition to potentially prolonging T-cell activation, the aberrant expression of MICA may also be involved in modulating the responses of NK cells in the inflamed synovium.
For example, ATHB4 has previously been characterised as a regulator of shade avoidance, being strongly up-regulated by far red light, and modulating the responses to auxins, brassinosteroids and gibberellins in seedlings [ 57].
It is also possible that aberrant expression of MICA in the inflamed synovium [ 57] is involved in modulating the responses of this subset of NK cells, resulting in the dysregulated production of proinflammatory cytokines rather than in immunoregulation.
The chromosomal damage associated to these treatments could last long time after the exposure, affecting the baseline MN frequency and potentially modulating the responses to the challenge agent in vitro.
These findings, together with the observation that at variance with Ro 32-0432, rottlerin was only partially effective in reverting the effect of PMA (Table 2), may suggest that different isoforms of the enzyme play distinct roles in modulating the responses to TTN.
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This study provides a criterion for assessing the importance of vadose zone in modulating the response of unconfined aquifers to low-frequency forcing oscillations such as tides.
The striatum exerts its proactive control possibly by modulating the response threshold in M1 [63], [64], [64].
We examined the role of G proteins in modulating the response of living cells to receptor activation.
The extent of microbial translocation may be one factor modulating the response to low-level HIV replication.
The UPR and NMD mechanisms have an important role in modulating the response to readthrough treatment.
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