Sentence examples for modulating the resistance from inspiring English sources

To examine the role of the 5′ leaders in modulating the resistance to eIF2 inhibition of resistant mRNAs revealed in this study (IFRD1, PPP1R15B, UCP2, PTP4A1, and SLC35A4), we designed reporter constructs and prepared capped and polyadenylated mRNAs with sequences of 5′ leaders upstream of a Firefly luciferase (Fluc) coding region.

AtHUB1 acts independently of JA but ET and SA are involved in modulating the resistance of athub1 mutants to necrotrophic fungi [ 13].

In these sensors, the charge carriers generated during Pd hydridation are transported to the semiconductor channels and modulate the resistance.

Overexpression or silencing of these CPKs might modulate the resistance to E. amylovora infection.

Moreover, mutations inducing allelic variation in an antibiotic resistance gene could also modulate the resistance level conferred by a gene.

Almost any nutrient deficiency can modulate the resistance to infections, as most nutrients are involved in the immune response.

In addition some amino acids in the LRR domain modulate the resistance by interacting with host factors [ 45].

Thus, it was confirmed that GNA could activate the apoptosis-related proteins caspase-3 and caspase-9 to induce apoptosis in MCF-7/ADR cell lines, which modulated the resistance to ADR to some extent.

These results show that late pre-osteoclasts are capable of signaling via JAK-STAT1, and suggest that signaling events distal to TRAF6 and STAT1 modulate the resistance of these cells to IFN-γ.

The induction of DNA hypomethylation appears to require lower doses of azacitidine than does cytotoxicity [ 22] and may modulate the resistance mechanisms in patients with platinum-refractory advanced solid tumors; in fact, azacitidine was shown to enhance the sensitivity of platinum-resistant ovarian cancer cells to carboplatin [ 23].

These data suggest that the mechanism of mechanical unfolding is conserved in proteins within the same fold family and demonstrate that although the topology and presence of a hydrogen-bonded clamp are of central importance in determining mechanical strength, hydrophobic interactions also play an important role in modulating the mechanical resistance of these similar proteins.