The proximity of Rpb4/7 to the flexible clamp and its influence on clamp position in low-resolution structures suggest that the heterodimer may modulate the position of this flexible module [ 84, 85].
The pressure probe can be used to modulate the position of the meniscus and follow the dynamics of the pressure until a steady state is reached, with a half-time τ.
It is tempting to speculate, however, that deprotonation of Glu could release it from its resting position and the resultant conformational change facilitate an interaction with nearby His, which could, in turn, modulate the position of His relative to the proximal cluster during the catalytic cycle.
Although we did not detect a gross difference in the variability of inter‐head distances in the DDB complexes compared to dynein alone, it is conceivable that the interaction of dynactin with domain 3 of the dynein tail allosterically modulates the positions or orientations of the heads and thus biases the motor into a processive conformation.
In this sense, each set controls interaction networks that, in principle, modulate the positioning of the DBD at each one of these respective diagonals (double arrow at Figures 8-C and D) and that, taken all together, can regulate small translation and rotation movements for the DBD around the entire major groove's inclined plane.
Moreover, it provides a promising strategy for modulating the band positions of RGO. Figure 4 Mechanism of in-situ photoelectrochemical reduction of GO in a DSSC assembly.
Although DNA polymerases can modulate the backbone position of the templating nucleotide, perturbing the position of the α-phosphate of the incoming 8-oxodGTP to accommodate an anti conformation would be expected to severely compromise its insertion.
Second, interactions between charged portions of the ATP molecule and the side chains of D110 and D185 could modulate the Mg2+ position and stability for DNA polymerization [1].
Chromatin organization also plays a role in transcriptional initiation by modulating the accessibility and positioning of both cis- and trans-regulatory elements.
The possibility of modulating the T-cell centrosome position with well-studied drugs and of predicting their effects in silico appears attractive for designing anti-cancer and antiviral therapies.
