Sentence examples for modulating the phosphorylation from inspiring English sources
We may also conclude that, by modulating the phosphorylation level of laminin, TNAP impacts on the interaction between PrPC and laminin.
These observations suggested that the increased levels of the IFI16 protein under glucose restriction modulate the p53-mediated cell survival by modulating the phosphorylation of p53 and the expression of its target genes.
Besides, we provide evidence that the PrPC-interacting protein laminin is a substrate for TNAP in 1C11-derived neuronal cells, and that, by modulating the phosphorylation level of laminin, TNAP impacts on the interaction between PrP and laminin.
Since DPI is a NADPH oxidase inhibitor [38] and several studies have demonstrated that PKC has a central role in the regulation of NADPH oxidase [39], [40], modulating the phosphorylation and activation of p67phox [41] and p47phox components [16], it is reasonable to assume that PKCδ acts upstream of ROS production, DNA oxidation and apoptosis.
50 It is known that Cdc25 C phosphatases and Wee 1 kinase play critical roles in maintaining G2 phase arrest through modulating the phosphorylation of Cdc2.
Possible cooperation between GNF-2 and AKIs in modulating the phosphorylation of Bcr-Abl T315I protein was also tested using cell-based auto-phosphorylation assay.
Modulating the phosphorylation-mediated dimerization in the receiver domain may interfere with the transcriptional function of PhoP.
CDK4/cyclin D complexes and other Ras-related kinases modulate the phosphorylation of SMAD3 [30], [31], [31], and this modulation of SMAD3 causes its downstream signaling to change from tumor suppressive to oncogenic [29], [30].
To explore this, we determined whether eHsp90 modulated the phosphorylation status of EphA2S897.
Finally, TNAP activity is shown to modulate the phosphorylation status of laminin and thereby its interaction with PrP.
PINK1 has also been proposed to modulate the phosphorylation status of another mitochondrial protein Omi/HtrA2, possibly through indirect mechanisms [28].
