Sentence examples for modulating the nuclear from inspiring English sources

Additionally, DAG activates the Ras/extracellular regulating kinase (Erk) pathway, modulating the nuclear factor Fos. Through all of these interacting signaling pathways, T cells are activated, releasing numerous cytokines and chemokines, including IFN-γ, Granzyme B, and IL-2 (Abraham and Weiss, 2004; Smith-Garvin et al., 2009).

Since ATRA acts throughout events that require extensive changes of nuclear architecture and activity and considering that Vav1 accumulates inside the nuclear compartment of differentiating APL-derived cells, the possible role of this protein in modulating the nuclear proteome was investigated.

Our results also show that calcium influences the ERK5 cascade by modulating the nuclear translocation of MEKK2 as well.

Anti-inflammatory effect of ENERGI-F704 was attributed to modulating the nuclear translocation and stability of NF- κB.

Moreover, some studies have reported that glutamine down-regulated the intestinal inflammatory response in experimental models [ 31, 34- 36] by modulating the nuclear factor-κB (NF-κB) pathway [ 37- 40].

Intracellular calcium also modulates the nuclear translocation of the downstream regulatory element antagonist modulator (DREAM), which plays a role in endogenous responses to pain [27, 28].

These differences in subcellular localization of both FoxM1 and p27Kip1 in the Igf1−/− mouse cochlea suggested that FoxM1 may modulate the nuclear targeting of p27Kip1.

Since phosphorylation of FOXO3a was found to cause nuclear exclusion and consequently, inhibition of its transcriptional activity, we decided to examine whether SPHK1 modulated the nuclear expression of FOXO3a.

Niclosamide also modulated the nuclear factor-κB and STAT3 pathways in MM cells.

Bag-6 (Scythe) modulates the nuclear pathway that communicates with mitochondria and regulates the release of cytochrome c thereby controlling apoptosis [ 11, 12].

In this respect, the capability of TRAIL-R1 and TRAIL-R4 to specifically interact with TRAIL-R2 in the nucleus also raises the question of the capacity of these receptors to modulate the nuclear functions of TRAIL-R2.