Sentence examples for modulating the methylation from inspiring English sources
Indeed, we found that neither age nor natural hormone levels are modulating the methylation levels.
First, it may regulate the epigenetic state of chromatine, modulating the methylation state of DNA and/or histones [27], [43], [44].
Other reports have shown that totally or partially intronic long antisense transcripts may have regulatory functions, such as modulating the methylation status of promoters [ 18] or the alternative splicing pattern of the corresponding protein-coding gene [ 19].
We used human adipocytes as the model system and show that vitamin B12 restriction induced cholesterol biosynthesis in adipocytes by limiting cellular AdoMet levels and modulating the methylation of genes which regulate cholesterol biosynthesis.
Modulating the methylation status of cytosine can generate epialleles, which have been detected and characterised at specific loci in several plant systems, and have the potential to generate novel and relatively stable phenotypes.
The results presented thus far clearly show that the degron-protease-blockade-methylation sensor is sensitive and specific enough to enable imaging of histone methylation marks, both in cells and in small animals, and is suitable for preclinical evaluation of small molecule inhibitors capable of modulating the methylation of histone proteins at specific lysine residues.
As we show in two examples in Figure 3, the SNPs (rs16891982 and rs12913832), known to encode pigmentation in humans [23], [25], [29], appear to modulate the methylation level of other genes (PM20D1 and SLC44A4).
Moreover, it is unclear if meSNPs modulate the methylation status of nearby CpG sites.
Our observations confirm the importance of age as a major determinant of CGI methylation for most of the genes investigated, but also strongly suggest that folate status, and other nutritional and metabolic factors, modulate the methylation of specific genes.
Because TMCG/DIPY treatment modulates the methylation status/stability of E2F1, the results demonstrate that therapies targeting the epigenetic machinery of cancer cells in the presence of overexpressed E2F1 may result in efficient E2F1-mediated cell death.
Because TMCG/DIPY treatment modulates the methylation status and stability of E2F1, we observed that the 4OHT-dependent overexpression of E2F1 positively influences E2F1-mediated cell death in ERα-negative ERα-negativer cells.
