Sentence examples for modulating the intracellular from inspiring English sources
Selective inhibition of phosphodiesterase (PDE) 4B favorably suppresses the synthesis of inflammatory cytokines and subsequently arrest the development of atopic dermatitis via modulating the intracellular cAMP levels.
SLC39A14 may regulate PDE activities by modulating the intracellular Zn level [56], [57] in tissues that express SLC39A14 and contain high concentrations of Zn [20], [58], [59].
The products of the FGF synexpression group are then capable of modulating the intracellular signaling cascades of several FGF ligands, in particular FGF8, to curtail or achieve specific spatial patterns of FGF signaling [10].
By modulating the intracellular pH and thereby increasing the activity of β-galactosidase, glycolytic enzymes and lactate dehydrogenase, urease increases the overall change in enthalpy generated by the bioenergetic reactions.
In particular, the thioredoxin (Trx) system, composed of thioredoxin reductases (TrxR), thioredoxins and NADPH [51] is known to participate in modulating the intracellular redox environment and thiol/disulfide exchange, rendering difficult to single out the effect of GSH per se in the context of the overall redox state [52].
Together, they have the ability to uptake/efflux structurally and functionally dissimilar cytotoxic agents, thereby modulating the intracellular drug concentration.
Agents which can stop OS multi-stressor events and modulate the intracellular redox state are becoming a major focus in HCC prevention.
Oral administration of HIE, lowers the FBG of STZ induced diabetic mice as well as it modulates the intracellular antioxidant defense to overcome the oxidative damage and improves the serum lipid profile.
The 5' end terminus of the transcripts initiated at residue −31 is extremely GC-rich, and may fold into a relative stable hairpin which could influence translation and thus modulate the intracellular levels of galectin-1.
Given the importance of the NP's protein corona in mediating interactions between NPs and cells (e.g., cellular uptake and subsequent intracellular transport) [30 33], we hypothesized that the presence and absence of serum proteins during NP-cell interaction may importantly modulate the intracellular agglomeration and spectral shift accompanied by nanoparticles.
The conserved S75 and S90 adjacent to the PDZ domain are especially relevant as these phosphosites modulate the intracellular compartmentalization of β2-syntrophin and its interaction with ICA512.
