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These regions are involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis that controls reactions to stress as well as mood and emotions (Canteras et al., 2010), suggesting that VEGFR3 signaling in NSC/astrocytes may act on behavior by modulating the functioning of the limbic-HPA axis.
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Membrane cholesterol plays an important role in modulating the function of several membrane proteins.
Describing, understanding, and modulating the function of the cell require elucidation of the structures of macromolecular assemblies.
Additional domains coupled to the same polypeptide are important for modulating the function of these ubiquitin ligases.
Recently, aptamers have proven to be valuable tools for modulating the function of endogenous cellular proteins in their natural environment.
Current evidence suggest that PACAP plays essential roles in the pathogenesis of migraine via modulating the function of nociceptive neurons within the trigeminocervical system.
Collectively, these data suggested that the EBR system may be involved in modulating the function of pulmonary endothelial cells and reducing the adhesion and chemotaxis of neutrophils.
Fourth, Txnip can promote apoptosis by modulating the function of the apoptosis signal-regulating kinase 1 (ASK1) [15, [15].
Ultimately, we expect that therapeutically modulating the function of specific populations of inflammatory cells during distinct phases of the disease will ameliorate specific features of the pathology.
We also investigated the role of PKG signaling in modulating the function of sarcKATP channels in ventricular cardiomyocytes isolated from adult rabbits.
It is therefore possible that MISC-1/OGC affects insulin secretion by modulating the function of Bcl-2 proteins, probably through regulation of Ca2+ release from mitochondrial stores.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com