Membrane cholesterol plays an important role in modulating the function of several membrane proteins.
Unlike enzymes, directly modulating the function of a transcription factor requires specific disruption or recruitment of DNA-protein or protein-protein interactions.
Recently, aptamers have proven to be valuable tools for modulating the function of endogenous cellular proteins in their natural environment.
Additional domains coupled to the same polypeptide are important for modulating the function of these ubiquitin ligases.
Describing, understanding, and modulating the function of the cell require elucidation of the structures of macromolecular assemblies.
have been reported to be pharmacologically active in the brain by modulating the function of several ionotropic receptor systems and voltage-sensitive ion channels.
Neurons process information encoded in the form of synaptic potentials and action potentials, with excitatory neurons promoting action potential firing in their targets, inhibitory neurons limiting and controlling the timing of action potential firing, and other neurons modulating the function of excitatory and inhibitory neurons.
MicroRNAs (MiRs) are small noncoding RNAs with regulatory effects on biological process, and it has been recently shown that they can control inflammatory process and the response to an infection by modulating the function of TLRs.
The post-translational modification of proteins by the covalent attachment of carbohydrates to specific side chains, or glycosylation, is emerging as a crucial process in modulating the function of proteins.
It was shown that the interaction of FANCM and the FA core complex is important for ID2 recruitment and mono-ubiquitination34, and thus the defect of FANCM-MM1 mutant in CFS protection is likely related to modulating the function of the FA core complex and ID2, which is in line with the previous findings that the FA core proteins and ID2 are important for CFS protection14.
Collectively, these data suggested that the EBR system may be involved in modulating the function of pulmonary endothelial cells and reducing the adhesion and chemotaxis of neutrophils.
