Sentence examples for modulating the dna from inspiring English sources

A comparative study also revealed that the spacer length is also significant in modulating the DNA binding affinities.

As ligand binding induces the dissociation of RXR tetramers into dimers, it can alter gene expression by modulating the DNA architecture.

Mutations in one of the DNA repair genes are one of the most common reasons for cancer, and it may be assumed that the individual genetic background modulating the DNA repair capacity may affect the susceptibility to cancer.

These results may have important implications for studies of TFs not just in human but across all eukaryotes, and suggest future studies focused on testing the roles of N- and C-terminal flanking regions in determining or modulating the DNA binding affinity and/or specificity of the associated TFs.

FOXM1 also contributes to modulating the DNA damage-induced apoptosis and senescence.

A role for hypoxia modulating the DNA methylation profile of cells has been described and is suggested to arise from hypoxic regulation of DNMT expression [ 79– 81].

Dimerization of TFs can function in modulating the DNA-binding specificity [ 10].

These observations suggest that the phosphorylation status of DNA-PKcs could both positively and negatively modulate the DNA repair activity of DNA-PK.

In this review, we examine how viruses harness the diversity of the cellular ubiquitin system to modulate the DNA damage signaling pathway.

A recent study showed that phosphorylation of Twist1 affected its dimer affinity for a given partner and modulated the DNA binding affinity, which might control limb development [10].

This suggests that both termini may actually modulate the DNA polymerase activity of Hspol γ by inhibiting its stimulation by HsmtSSBwt.