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These results demonstrated that metal nanoparticles may influence fibroblast function by negatively modulating the deposition of extracellular matrix molecules (ECM) and altering the expression of ECM receptors, cytoskeletal reorganization, and cell migration.
Additionally, CSF measurements do not provide information on regional brain deposition of Aβ or tau, which may have clear correlates with cognition or regional brain atrophy and might not be able to provide important information regarding the therapeutic outcomes or response to current drugs aimed at modulating the deposition of these misfolded proteins [ 19- 23].
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In order to increase the deposition rate of HPPMS, different combinations of frequency and pulse width at a constant duty cycle were used to modulate the deposition rate of the Ti film.
Analogue to the multilayer GeSi islands growth [27], vertically aligned GeSi nanowires were expected by modulating the amount of Ge deposition and the thickness of Si spacer layer.
It is also thought that TGF-β exerts a selective effect on ECM deposition by modulating the action of other growth factors on metalloproteinase and TIMP expression [ 35].
Modulating the experimental parameters for elastin deposition, a stable procedure was achieved, allowing elastin to link on PPF : DEF scaffolds with a suitable stability.
For instance, it has been shown that the ablation of CX3CR1 in AD mouse models, namely APP/PS1 and R1.40, attenuates Aβ deposition by modulating the phagocytic activity of microglial cells [ 57].
This receptor for CLC-1 seems to be intimately related to other matrix proteins, modulating the intensity of type III collagen deposition in the liver [ 63].
Auger electron spectroscopy confirmed that Cr2N and CrN bulk film stoichiometry was achievable by modulating the argon to nitrogen process gas ratio during deposition.
A new study shows that chromatin-bound Argonaute-1 and Argonaute-2 associate with splicing factors and affect the deposition of histone marks, thereby facilitating spliceosome recruitment and modulating the RNA polymerase II elongation rate.
Using different deposition techniques results however in different structural and electric properties, modulating the device performance.
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