The dominance of mutations will influence the extent to which population size and structure modulate the consequences of MA.
Various elements must be considered during the development of such new therapies, including the cellular context, which may greatly modulate the consequences of p53 activation.
The polyglutamine region has been shown to subtly but significantly modulate the consequences of endogenous full-length murine and human huntingtin in vivo (5, 6).
The in vitro preparation presumably reduces or eliminates structured activity in afferent sources of input that could either directly compete with or modulate the consequence of feedback inhibition.
The budding yeast offers a convenient system to monitor amyloid toxicity [5] [7] and has allowed in the past pinpointing genes that modulate the deleterious consequences in other eukaryotic models [8].
Although much is known about how dosage compensation is established, the consequences of modulating the stability of dosage compensation postembryonically are not known.
Environmental factors and/or the presence of a complex allele could modulate the initial consequence of the c.3909C>G mutation.
To identify strategies for rectifying defects in pathological VEGF neovessels, we investigated consequences of modulating the Rho GTPase Cdc42.
Two recently published experimental approaches illustrate the feasibility and consequences of modulating the defects caused by the alteration of this pathway.
