Sentence examples for modulating the conformation from inspiring English sources

It is tempting to propose the substantial conformational changes of the ARP module could play a role in modulating the conformation of the Snf2 ATPase domain, thus controlling the efficiency of SWI/SNF remodeling, which is consistent with previous functional and structural observations on the regulatory role of ARP module (Clapier et al., 2016; Xia et al., 2016).

Here, we show that post-translational modifications and a patient-derived mutation regulate pyruvate kinase activity of PKM2 through modulating the conformation of the PKM2 tetramer.

The TFIIB B finger/B reader plays a role in modulating the conformation of TFIIB [ 1, 11, 24].

We propose a novel role for interfacial structural elements in modulating the conformation of the active site for optimal activity.

Calcium-binding at Ca3 5 likely promotes calcium binding at the Ca2 site by modulating the conformation of a loop (residues 369 389) that connects these two regions of the enzyme.

This mechanism would thus allow microtubules to regulate kinesin's affinities for ADP and ATP by modulating the conformation of the switch loops, yielding an elegant structural basis for kinesin's nucleotide-binding behavior on and off microtubules.

These intracellular signals can regulate integrin receptor adhesiveness by modulating the conformations and the degree of binding to ECM ligands, regulating, for instance, cell migration and growth [ 11].

The mobility of the Arp module may modulate the conformation of the ATPase domain as a conformational switch on the SWI/SNF remodeling activity.

To obtain a more complete and atomic-resolution understanding of how these insertions modulate the conformation of ubiquitin, we have solved the crystal structures of four insertional mutants of ubiquitin.

Thus, BBK32 and anastellin appear to modulate the conformation of Fn in similar ways and have similar biological activities.

The structural studies monitoring Med18-Med20 interaction with Rpb4/Rpb7 in S. cerevisiae reveal that Med18-Med20 modulathe the conformation of RNA Pol II, regulating its interaction with DNA.