Sentence examples for modulating the chromatin from inspiring English sources

We further showed that PARP1 influences splicing decisions by modulating the chromatin structure7.

The methylation status of lysine residues in histones determines the transcription of surrounding genes by modulating the chromatin architecture.

An intricate network of epigenetic factors regulates cell differentiation by modulating the chromatin structure and ultimately affecting gene expression.

Current studies involving the understanding of small RNA molecules such as noncoding RNA and microRNA in modulating the chromatin architecture are explained in depth here, along with effects of some novel compounds from recent preclinical and clinical evidence.

Therefore, REX1 also has a role in modulating the chromatin structure of hUCB-MSCs, which needs to be further explored.

Cell identity is defined by the interplay of DNA methylation, histone modifications microRNAs and DNA binding proteins, which shapes the transcriptional profile of each cell type, by modulating the chromatin landscape.

Escamilla-Del-Arenal, M. & Recillas-Targa, F. GATA-1 modulates the chromatin structure and activity of the chicken α-globin 3′ enhancer.

Collectively, our data suggest that PCL recognition of H3K36me3 promotes intrusion of PRC2 complexes into active chromatin regions to promote gene silencing and modulate the chromatin landscape during development.

Lysine methylation is of particular interest because it can modulate the chromatin structure to a compacted state or a relaxed one, depending on which lysine residues are methylated.

Consistent with this, NF-Y DNA binding activity modulates the chromatin structure of its target genes through the local maintenance of post-translationally modified histones, resulting in gene transcription modulation.

TFs with Jumonji domain (JmjC) function as histone demethylase and modulate the chromatin status [ 34].