Sentence examples for modulating the apoptotic from inspiring English sources

Moreover, this miRNA can indirectly regulate the levels of the oncogene MCL1, further modulating the apoptotic potential of CLL cancer cells by controlling cellular survival [ 104].

We speculate that both PGE2 and PGF2α derived from COX-2 could be key factors in modulating the apoptotic effect in E1A-transfected cell lines.

Future work will need to be done to clarify the mechanistic role of the hypoxia/HIF-1 pathway in modulating the apoptotic response of NPCs after irradiation.

These findings suggest that the downregulation of Bcl-2 expression by AS Bcl-2 enhances drug sensitivity by modulating the apoptotic signal transduction pathway of Bcl-2.

Based on this initial report, the aim of the present study was to further characterise the pathways modulating the apoptotic process in activated human HSCs.

These results are supported by the fact that HSP70 and HSP60 are overexpressed in cancer cells and have crucial roles in modulating the apoptotic pathways and in cancer development.

The study of mRNA profile of the transfected cells indicated that all Vpr proteins modulated the apoptotic genes triggering the intrinsic pathway of apoptosis.

Among the oncogenes, which may modulate the apoptotic process, Kit/Stem Cell Factor has a peculiar interest, since Kit is expressed in germ cells to some extent and Leydig cells, whereas SCF is expressed in Sertoli cells.

Both triterpenes successfully modulated the apoptotic response, promoting nuclear condensation and fragmentation.

The PKC δ and η also modulate the apoptotic response of keratinocytes exposed to UVB [36], [37].

We then investigated the potential mechanism by which cyclin D1 might modulate the apoptotic response.