Besides the activation of KATP channels, GLP-1 is also involved in modulating the activity of the voltage-gated potassium channels (Kv) [ 3, 8, 9].
This is known as "top-down processing," since the prefrontal cortex (the "top" of the brain) is directly modulating the activity of other areas.
Most researchers believe that two commonly administered drugs, donepezil and memantine, which aim at modulating the activity of key neurotransmitters, have limited short-term effect and do nothing to slow the progression of the disease.
This compound might interfere with cell migration by modulating the activity of different upstream target kinases.
Agents capable of selectively modulating the activity of these enzymes are of potential therapeutic value.
They predominantly use (non-genomic) signaling pathways common for neuromodulators such as modulating the activity of several neurotransmitter receptors.
Modulating the activity state of Rho, Rac, and Cdc42 in neurons can modulate the growth cone response to collapsing agents.
Many non-coding genetic variants within risk-associated loci alter gene expression by modulating the activity of cis-regulatory elements.
We conclude that manganese regulates cytoskeletal organization in astrocytes by modulating the activity of p115RhoGEF and RhoA.
We suggest interface swapping in dimers could be a general mechanism of modulating the activity of transcription factors.
These diverse modifications are read out by effector protein complexes, which ultimately determine their functional outcome by modulating the activity state of underlying genes.
