Sentence examples for modulating the active from inspiring English sources

These findings showed that cytochalasin B inhibited glucose uptake and transport by modulating the active binding sites of GLUTs and not by degrading the actual GLUTs protein contents.

It is known that pathogenic mutations near the C-terminus of the Aβ sequence in APP can lead to increased generation of Aβ42 by modulating the active sites of γ-secretase.

The distinction between residues that are directly involved in catalysis through, for instance, nucleophilic attack or proton transfer (such as D105 and H300) and those that act by electrostatically modulating the active site is proving to be subtle.

In summary, the above experimental results suggest that the pZBD in GluRS not only affects the local interaction with tRNAGlu acceptor arm (thus modulating the active site) but also affects the catalytic step of glutamylation reaction indicating some distant communication with other part of the protein.

NZ modulated the active region structure and completed the MBE growth.

PV system is by nature a controlled current source, where different electrical control strategies are incorporated to modulate the active and reactive current outputs.

The soma to germ transformation in these mutants is antagonized by the ISW-1 complex and the MES-4 complex (Cui et al., 2006; Stielow et al., 2008), which appear to modulate the active chromatin structures.

However, further studies are required to examine how these mutations modulate the active conformation of vinculin in FAs.

This report accordingly highlights the potential role of RNA helicases, RNA chaperones, or RNA annealers that are expected to either directly affect the sequential enzymatic action of NS5B and/or to modulate the active structure of the RNA template.

In Cg10062, His-69 is replaced with an isoleucine, which could affect this interaction and perhaps alter the position of His-28 and/or otherwise modulate the active site properties.

Additionally, whether or not Ca plays a role in modulating the redox-active cluster is still an open question, but recent studies with heteronuclear Mn and Ca/Sr complexes have implicated the role of Ca in this process.