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This change in the F1P pool could have global metabolic effects through modulating the actions of the catabolite repressor/activator protein Cra (also known as FruR).
Although other reports have pointed to individual pathways modulating the actions of some OPN splice variants in different tumor models [ 5], none of them has investigated putative interacting signaling networks and their relationships to functional data.
Furthermore, heparin may be capable of modulating the extent of remodelling of the airway wall seen in asthma by modulating the actions of a range of proteins including ECM proteins, growth factors and certain enzymes, and by inhibiting the proliferation of lung fibroblasts and airway smooth muscle cells [ 58].
Because the window for PTH stimulation of OB differentiation in Cox-2 KO cultures was early in culture and because PGs cause PTH to decrease both OB and adipocyte differentiation, it is possible that PGs are modulating the actions of PTH on MSCs, which are likely to be available only early in culture.
However, this residue is not conserved among suramin sensitive receptors, and it has been suggested that it is the localized positive charge that is important in modulating the actions of the negatively charged suramin (Braun et al., 2001; Sim et al., 2008).
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Instead of focusing on the receptors blocked by PCP, Dr. Schoepp concentrated on modulating the action of glutamate receptors in the brain's prefrontal cortex, an area responsible for personality and learning.
NF-κB controls the cell-cycle progression by modulating the action of cell-cycle regulatory proteins.
In other words, eye position alone was not the critical factor modulating the action epoch.
Several studies have suggested that curcumin interacts with the TGF-β signaling cascade, modulating the action of TGF-β.
Certainly, eye-position signal per se is not the critical factor modulating the action epoch (HOLD) of this cell.
Thus, c-Src appears to have pleiotropic effects on cancer cells by modulating the action of multiple growth-promoting receptors.
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