Sentence examples for modulating the SREBPs from inspiring English sources

In mammalian cells, MED15 acts as an important regulator of lipid biosynthesis through modulating the SREBPs (Yang et al. 2006).

In the present study, we performed a detailed analysis of the proximal promoter of DHCR24 that allowed the identification of a functional SRE as well as putative cis-acting elements that may modulate the SREBP-mediated regulation.

Epigallocatechin-3-gallate, the major polyphenol in green tea, was found to reduce sebum by modulating the AMPK-SREBP-1 signaling pathway and inflammation through suppression of NF- κB and AP-1 pathways.

The canvas grins through, modulating the whiteness.

To identify novel regulators of SREBPs, we performed a genome-wide cDNA over-expression screen to identify proteins that might modulate the transcription of a luciferase gene driven from an SREBP specific promoter.

The mature processed form of SREBP is released in the cytosol and can translocate into the nucleus where it modulates the expression of several genes controlling cholesterol and fatty acid homeostasis (Horton et al, 2002), including hydroxymethyl glutaryl-CoA reductase (HMGCR), HMG-CoA synthase (HMGCS), low density lipoprotein receptor (LDLR) and SREBP1/2 itself.

We modulate the temperature.

Saccharin directly modulates the microbiota.

It helps modulate the speed of neurotransmission.

There is no transcriptional evidence to suggest that this coordinate up-regulation of lipogenesis in myoblasts, normally considered an insulin response, is modulated by the hierarchical SREBPs.

One important family of transcription factors that controls lipid synthesis is the SREBPs.