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Astrocytes are the most abundant glial cells in the brain and are responsible for diverse functions, from modulating synapse function to regulating the blood brain barrier.
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We conclude that glycans play a primarily inhibitory role in modulating synapse morphogenesis.
Thus, it is clear that ephrin receptors modulate synapse formation in the HC and related cognitive functions.
MMP-7 has also been shown to modulate synapse morphology.
These receptors have been reported to modulate synapse formation and glutamatergic long-term potentiation (LTP) (for a review see [ 51]).
If dopamine modulates glutamatergic synapse function in developing SPNs as it does in mature circuits, it likely interacts with glutamate-dependent neural circuit development during the early postnatal period.
Thus, SALMs regulate excitatory and inhibitory synapse function through distinct mechanisms.
Synapses are destroyed in numerous other neurological diseases, including Alzheimer's, in which the gradual decline of memory function is likely due to loss of synapses in the hippocampus, and major depressive disorder, which is known to involve altered synapse function in the prefrontal cortex.
These include genes involved in axon guidance, axonal growth, synapse structure and synapse function.
Physiological measures of synaptic transmission showed that Akt1 function is required for normal synapse function.
NL2 also regulates the balance between glutamatergic and GABAergic synapse functions by selectively modulating inhibitory synaptic transmission.
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