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Using a human glioblastoma cell line (GBM), we explored the possibility of modulating susceptibility to Fas/CD95-mediated apoptosis following cytotoxic treatment.
Collectively, data suggests a role for IL-23 not only in C. jejuni-mediated host immunity, but it may also prove pivotal in modulating susceptibility to IBD post-C.
Biological, genetic and environmental factors may intervene in modulating susceptibility to insecticides.
Polymorphisms in Epidermal Growth Factor Receptor (EGFR) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung cancer.
Finally, while our analysis did not detect a common SNP significantly associated with SAB acquisition, it remains possible that rare genetic variants are modulating susceptibility to SAB.
Future larger studies have to target epigenetic modifications and also other non-SNP variations (e.g., copy number variations, gene deletions/duplications) in the CGB genes, which may have clinical importance in modulating susceptibility to pregnancy loss.
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The vaginal microbiota may modulate susceptibility to human papillomavirus (HPV), Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections.
Gene products of ABC transporters may thus serve as the targets for agents that may modulate susceptibility to drugs, by inhibiting drug transport.
The long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental interactions that modulate susceptibility to renal disease and intermediate phenotypes.
DNA double-strand break repair via homologous recombination (HR) is essential in maintaining genetic integrity, and may modulate susceptibility to the development of acute myeloid leukemia (AML) and influence outcomes of AML.
Antibody-mediated neutralization of virions bearing high amounts of GP was slightly more efficient than neutralization of virions harboring low amounts of GP, suggesting that the efficiency of GP incorporation into virions might modulate susceptibility to neutralizing antibodies.
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