These ubiquitously expressed enzymes exhibit a multitude of regulatory cellular functions and are specialized in modulating structure, localization, and activity of their substrates [ 66, 67].
These results indicate that anionic groups play a crucial role in modulating the structures of water clusters with their spatial structure and binding sites.
Thus, the ability to modulate the structures of glycans on cell surfaces provides a powerful means not only to understand fundamental processes but also to direct activity and elicit desired cellular responses.
REV is a putative activator of SIRT1, a NAD-dependent histone deacetylase that can regulate gene expression by modulating the structure of chromatin [ 19].
Overall, this research provides an efficient platform for precisely modulating the structure of MOF-based carbons to develop multifunctional hollow architectures for satisfying enormous demands in upcoming energy devices.
Although most drugs bind to proteins and regulate their activity, some drugs act through a new therapeutic approach called membrane-lipid therapy and bind to lipids, thus modulating the structure of membranes.
At the postsynaptic site, Zn2+ ions are recruited into large macromolecular platforms within the PSD, assembled by scaffolding molecules such as ProSAP2/Shank3 and ProSAP1/Shank2, thus modulating the structure of the protein meshwork underneath the postsynaptic membrane [23] [26].
These results are supported by phenotypes of KO mice and suggest that when an animal enters a state of positive energy balance adipose tissue expansion is initiated by coordinate changes in mRNA levels for proteins required for modulating the structure of the caveolae to maximize the capacity of the adipocyte for lipid storage.
Organisms living in polar regions have evolved a series of antifreeze (glyco) proteins (AFGPs) to enable them to survive by modulating the structure of ice.
From a structural standpoint, binding of a protein to Cyt c could potentially affect heme ruffling by modulating the structure of the loop.
