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The involvement of natural antibiotics in modulating secondary metabolism at subinhibitory concentrations suggests that they represent part of the microbial vocabulary through which inter- and intraspecies interactions are mediated.
Inhibition of cell growth through modulating secondary lens fiber cell differentiation might provide a strategy to delay the onset and/or slow down the progression of this common visual impairment.
The ermE*p is a strong promoter that has been used in Streptomyces for protein expression [ 18, 19] and modulating secondary metabolites production [ 20- 22], making it useful for this study.
Implications regarding the mechanism of aggregation of this peptide into fibrils and the role of the environment in modulating secondary structure are discussed.
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The Dkk4 transgene in a wild-type background modulated secondary hair formation to a lesser degree than in Ta mice.
More recently, interacting MYB75 and KNAT7 transcription factors have been shown to modulate secondary cell wall deposition both in stems and seed coat in Arabidopsis [ 18].
The development of future curative treatments will therefore need to combine multiple approaches that are able to modulate secondary inflammation and to enhance endogenous regeneration.
Most importantly, we found that several other cell migration-related genes were modulated secondary to treating human TEC with ITGA6 specific siRNA, thus pointing to the notion that intra-TEC expression of genes involved in controlling thymocyte migration by the thymic microenvironment should be regarded as complex networks.
Herein, we report that trimethoprim triggers the production of over 100 compounds that are not observed under standard growth conditions, thus drastically modulating the secondary metabolic output of B. thailandensis.
Ultraviolet (UV) radiation modulates secondary metabolism in the skin of Vitis vinifera L. berries, which affects the final composition of both grapes and wines.
The rapid and reversible inhibition of end bud growth by experimentally implanted TGF-β1 demonstrates the mammotrophic activity of this growth factor, whereas its normally high concentration in the periductal extracellular matrix and its localized loss over lateral buds strongly implies an action that modulates secondary ductal growth [ 5].
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