Notably, Nef did not affect NF-κB activity in the absence of other stimuli, indicating that it modulates responsiveness to stimulation rather than activating NF-κB directly.
These data suggest that the GHRd3 polymorphism, shown to modulate responsiveness to GH using in vitro cellular models (2), may be associated with activation of different GH-signaling pathways, dependent on the level of endogenous GH present in the circulation.
Norman et al. [ 37], as previously stated that repeated exercise may show an increase in power performance in RR, though not in XX genotypes, suggesting that the ACTN3 genotype may modulate responsiveness to training in women [ 38, 39].
However, not only KRAS and BRAF as immediate downstream targets of the EGFR modulate responsiveness to anti-EGFR therapies.
The paucity of murine models of this "luminal" tumor subtype has hindered studies of factors that promote their pathogenesis and modulate responsiveness to estrogen-directed therapeutics.
In this study, inhibition of NOS2 by SMT and AG modulates responsiveness to inhaled NO in lungs of endotoxin (LPS -challenged rats in a dose-dependent manner.
However, the paucity of murine models of ERα+ tumors has hindered studies of the factors that give rise to this prevalent tumor subtype and modulate responsiveness to estrogen-directed therapeutics.
Androgen can modulate SCN responsiveness to light and can modulate SCN timekeeping in a dose-dependent manner [ 17].
A major issue is whether the spatial organization of a cell within this 3D tissue microenvironment could modulate cell responsiveness to regulate cell fate decisions such as survival, and if so how.
It should additionally be noted that the extension of the activations in anterior and ventral PFC regions into subgenual cingulate areas (Figure 3) indicates that the degree of personal relevance also modulated responsiveness in affective or emotional regions of the brain [30].
