Importantly, emerging data have also suggested that ribosome-associated cotranslational chaperones have active regulatory roles in modulating protein translation.
Other direct roles for Nt-acetylation include modulating protein complex formation [ 11], preventing post-translational endoplasmic reticulum (ER -translocation [ 12], as wER -translocation protein function and subcellular localization [ 12] 15].
61/SecY-mediated protein translocation across membranes.
Researchers now understand that certain stem loop structures in mRNAs make it possible for proteins to bind to them, often causing RNA degradation and subsequently modulating protein synthesis.
Rapoport, T.A. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
McFeeters, R. L. et al. The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS.
The overexpression of Hha (haemolysin expression modulating protein) causes cell lysis and reduction of biofilm formation as well as increases biofilm dispersal18.
Santini, C. L. et al. A novel sec-independent periplasmic protein translocation pathway in Escherichia coli.
Moreover, Ssc1 has been proven essential for protein translocation into the mitochondrial matrix26.
Schendzielorz, A. B. et al. Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.
