Sentence examples for modulating protein stability from inspiring English sources

We propose that Grp58 regulates β-catenin expression via modulating protein stability, but not gene transcription.

It is also noteworthy that, in addition to its transcriptional coactivator role, CARM1 also regulates target gene expression by modulating protein stability, including p/CIP [ 27], AP-1 [ 28], and NF-κB [ 29].

The ∼6 μM affinity for urate also rationalizes the modest effect of 6 μM urate in modulating protein stability, as only ∼50% of MftR would have urate bound at this concentration of ligand.

Importantly, this diagram helps predict differential expression of the genes that may have profound biologic consequences (i.e., by modulating protein stability or activation level) that are not observable in a gene expression microarray.

Palmitoylation will enhance the surface hydrophobicity and membrane affinity of protein substrates, and play important roles in modulating proteins' trafficking, stability, and sorting, etc [ 42, 44, 45].

Finally, the modulating effect of 17AAG on the protein stability and transcription of Nutlin-induced p21, PUMA and MDM2 was p53-dependent, as it was only present in HCT116 p53+/+ but not in p53−/− cells.

These cis-elements play critical roles in deciding the fate of the mRNA via various mechanisms, including co-transcriptional processing, modulating protein translation, mRNA localization and trafficking, and mRNA degradation and stability [ 1].

Importantly, emerging data have also suggested that ribosome-associated cotranslational chaperones have active regulatory roles in modulating protein translation.

The role of mosisture in protein stability.

Researchers now understand that certain stem loop structures in mRNAs make it possible for proteins to bind to them, often causing RNA degradation and subsequently modulating protein synthesis.

Regulation of TET Protein Stability by Calpains.