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In contrast, few changes in mRNA abundance are observed, indicating that regulation of translation is the primary mechanism of modulating protein expression during mitosis.
These findings underline the role of Bcl-xL protein as a resistance factor in colon cancer and as an attractive target for therapeutic concepts capable of specifically modulating protein expression such as in AS oligonucleotides strategies.
While somatic cells appear to use transcriptional regulation as a major mechanism for modulating protein expression during the cell cycle, translational regulation has been described in somatic cells as well (Sivan and Elroy-Stein, 2008; Novoa et al., 2010; Kronja and Orr-Weaver, 2011; Aviner et al., 2013; Stumpf et al., 2013).
These results suggest that miRNAs contribute to psoriasis pathogenesis by modulating protein expression and cellular functions in both keratinocytes and infiltrating immune cells.
If miRNAs are involved in regulating hES cell differentiation by modulating protein expression, then levels of miRNA expression would change when hES cells are induced to differentiate.
Yeast is an adaptive organism that survives in a variety of environments by modulating protein expression and activity, such as during the fermentation phase [25] where the natural habitat of the yeast is commonly the acidic surrounding of a fruit or within its confines.
Similar(52)
RDD and PHD could prevent the OVX-induced loss of bone mass; their preventive effects depended on modulating protein and mRNA expression of OPG and (or) RANKL in OB and bMSC.
The overexpression of Hha (haemolysin expression modulating protein) causes cell lysis and reduction of biofilm formation as well as increases biofilm dispersal18.
In this work, we investigated the mechanism by which Hha (hemolysin expression modulating protein) controls E. coli biofilm formation.
We discovered previously that the small Escherichia coli proteins Hha (hemolysin expression modulating protein) and the adjacent, poorly-characterized YbaJ are important for biofilm formation; however, their roles have been nebulous.
In a recent study, Dr Mrutyunjay Suar and colleagues investigated the impact of a hha (hemolysin expression modulating protein) mutation in TTSS2-deficient S. Typhimurium with respect to systemic colonization and reactivity to immunocompromised hosts.
More suggestions(16)
modulating gene expression
modulating protein function
modulating caspase expression
modulating immunoglobulin expression
modulating protein activity
modulating protein structure
modulating protein phosphorylation
modulating protein biosynthesis
modulating protein tyrosine
modulating protein mutation
modulating protein stability
modulating protein production
modulating protein clearance
modulating protein degradation
modulating protein condensation
modulating protein aggregation
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