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However, growing evidence suggests that Aβ may influence α-syn pathology by modulating protein clearance, driving inflammation, activating kinases, or directly altering α-syn aggregation.
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Importantly, emerging data have also suggested that ribosome-associated cotranslational chaperones have active regulatory roles in modulating protein translation.
Researchers now understand that certain stem loop structures in mRNAs make it possible for proteins to bind to them, often causing RNA degradation and subsequently modulating protein synthesis.
McFeeters, R. L. et al. The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS.
The overexpression of Hha (haemolysin expression modulating protein) causes cell lysis and reduction of biofilm formation as well as increases biofilm dispersal18.
Fibronectin (FBN) is a phagocytosis modulating protein and, as such, could be related with the infectious condition.
However, these approaches mostly overlook the incorporations of post-translational modifications, which nature extensively uses for modulating protein activities in vivo.
Ubiquitination is an important regulatory process for protein, playing diverse roles in modulating protein function.
We will focus on how these observations have impacted our understanding of the therapeutic potential of modulating protein phosphorylation in human diseases and areas in which future research in CML pathophysiology may be important.
In this work, we investigated the mechanism by which Hha (hemolysin expression modulating protein) controls E. coli biofilm formation.
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates cell growth and proliferation by modulating protein synthesis and transcription.
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