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The present study showed that the rexinoid bexarotene (LGD1069) exerts its chemopreventive activity by affecting multiple cellular pathways, not only targeting cancer-causing genes related with cell proliferation, differentiation and apoptosis, but also by modulating protein biosynthesis and mitochondrial bioenergetics.
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Activation of mTORC1 regulates cell growth by modulating protein synthesis, ribosome biogenesis and autophagy [ 29].
Interestingly, similar to constitutive CD4 expression also CD4 recovery of down-modulated T cells was dependent on protein biosynthesis.
Most genes included in module 3 encode chloroplast proteins such as 30S and 50S ribosomal proteins associated with protein biosynthesis in organelles, and chlorophyll biosynthesis related enzymes.
Importantly, emerging data have also suggested that ribosome-associated cotranslational chaperones have active regulatory roles in modulating protein translation.
Researchers now understand that certain stem loop structures in mRNAs make it possible for proteins to bind to them, often causing RNA degradation and subsequently modulating protein synthesis.
McFeeters, R. L. et al. The high-precision solution structure of Yersinia modulating protein YmoA provides insight into interaction with H-NS.
The overexpression of Hha (haemolysin expression modulating protein) causes cell lysis and reduction of biofilm formation as well as increases biofilm dispersal18.
Christian, B. E. & Spremulli, L. L. Mechanism of protein biosynthesis in mammalian mitochondria.
Yokozawa T, Oura H. Facilitation of protein biosynthesis by gin-senoside-Rb2 administration in diabetic rats.
Fibronectin (FBN) is a phagocytosis modulating protein and, as such, could be related with the infectious condition.
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