The ability of RA to stimulate GATA4/6 mRNA and protein expression, complex formation at GATA-DNA binding sites within the UP1B and UP2 promoter sequences, and UP induction in ESCs suggests mechanism(s) by which retinoids modulate progression of certain urogenital epithelial lineages through particular GATA transcription factors.
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) modulate progression of certain solid tumors.
These results support the concept that strategies aimed at normalizing a neoplastic-prone tissue landscape can modulate progression of neoplastic disease.
Strikingly, growing evidence indicates that LMO4 can modulate progression of breast cancer cell cycle by indirectly enhancing the expression of G1 cyclins, such as cyclin D1 and cyclin E, and contributes to the growth of multiple breast cancer cells (19– 219.
Cervical human papillomavirus (HPV) infection, a common sexually transmitted disease, is considered a necessary but not sufficient cause of cervical cancer, and attention is now focused on identifying cofactors which modulate its progression to high-grade cervical intraepithelial neoplasia (CIN) and invasive disease.
M. tuberculosis modulates its aggressive progression to disseminated forms of TB by modifying its transcriptome to acquire a phenotype with enhanced virulence that favors active infection and dissemination.
Previous functional analyses of the networks involved have found that, in addition to up-regulating those for mitigating the specific stressor, the majority appear to be involved in balancing energetic supply and demand and modulating progression through the cell cycle.
Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records.
Having multiple pregnancies increases the risk of HCV-related HCC among Egyptian women, raising questions about the roles of estrogens and other pregnancy-related hormones in modulating HCV infection and its progression to HCC.
Enteral nutrition has proved to protect against postoperative sepsis by supporting mucosal immunity and to modulate the progression from gut ischaemia to systemic inflammatory response syndrome.
