Genetic variants in the gene encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of ovarian steroid hormones.
These medications act by inducing mobilization of hematopoietic stem cells and by modulating production and release of neutrophils into peripheral blood.
Previous studies have assumed that varied abilities to tolerate torrid and humid environments among people are attributed to the differential capacities of their muscles to modulate production and release of heat [8 10].
The 6-O-isobutiryl and pivaloyl derivatives of methyl 3,4-O-isopropylidene-β-d-galactopyranosides as well the same 1-O-esters of 2,3-O-isopropylidene-α and β-d-mannofuranose exhibit biological activities much higher that the corresponding acids and could be proposed as possible agents to modulate production of embryo-fetal hemoglobins by human erythroid cells.
This suggests the involvement of reciprocal interactions whereby the epithelial cells feedback on the stromal cells to modulate production.
Earlier studies examining the ability of somatostatin to modulate production of IL-1 β, along with TNF- α and/or IL-6, are conflicting.
The timing of melatonin secretion interacts with gene transcription in the pituitary pars tuberalis to modulate production of TSH (thyrotropin), hypothalamic T3 (triiodothyronine), and tuberalin peptides which modulate pituitary production of regulatory gonadotropins and other hormones.
Both high activity (CSP-AU1 and CSP-NU1) and low activity (CSP-AU2) fractions were evaluated for their ability to modulate production of different cytokines in serum using a multi-cytokine semiquantitative ELISA array.
While SSRIs are known to modulate serotonin levels, it has been shown that they also modulate production of neurosteroids (e.g. allopregnanolone) that act as modulators of GABA receptors [ 13- 16].
Thus, these single-nucleotide polymorphisms (SNPs) can modulate production of IL-1β, directly affecting transcription [ 12, 13].
