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Genetic variants in the gene encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of ovarian steroid hormones.
Research over the past decade in inflammatory diseases such as psoriasis has focused upon modulation of cyclic adenosine monophosphate (cAMP), a naturally occurring intracellular secondary messenger that maintains immune homeostasis by modulating production of pro-inflammatory and anti-inflammatory cytokines [ 14, 15].
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While SSRIs are known to modulate serotonin levels, it has been shown that they also modulate production of neurosteroids (e.g. allopregnanolone) that act as modulators of GABA receptors [ 13- 16].
The 6-O-isobutiryl and pivaloyl derivatives of methyl 3,4-O-isopropylidene-β-d-galactopyranosides as well the same 1-O-esters of 2,3-O-isopropylidene-α and β-d-mannofuranose exhibit biological activities much higher that the corresponding acids and could be proposed as possible agents to modulate production of embryo-fetal hemoglobins by human erythroid cells.
Thus, these single-nucleotide polymorphisms (SNPs) can modulate production of IL-1β, directly affecting transcription [ 12, 13].
The timing of melatonin secretion interacts with gene transcription in the pituitary pars tuberalis to modulate production of TSH (thyrotropin), hypothalamic T3 (triiodothyronine), and tuberalin peptides which modulate pituitary production of regulatory gonadotropins and other hormones.
Here we found that the translation speed of ribosomes decreases at UCN serine codons and thereby modulates production of SinR and entry into biofilm formation.
Interestingly, activation of β2-adrenergic receptors on human peripheral blood T cells could modulate production of Th2 cytokines (e.g., IL-13)[ 17].
Earlier studies examining the ability of somatostatin to modulate production of IL-1 β, along with TNF- α and/or IL-6, are conflicting.
In mice, silencing Foxo3a has been shown to abrogate production of TGFβ1 (Watkins et al., 2011), an anti-inflammatory cytokine that can modulate production of other cytokines (Musso et al., 1990; Fadok et al., 1998).
Both high activity (CSP-AU1 and CSP-NU1) and low activity (CSP-AU2) fractions were evaluated for their ability to modulate production of different cytokines in serum using a multi-cytokine semiquantitative ELISA array.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com