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One of the major emerging functions of dopamine (DA) is its role in modulating plasticity in the striatum, cortex and hippocampus.
Roberts and Gavery [ 11] proposed a role for gene body methylation in modulating plasticity in which weak gene body methylation passively facilitates flexible gene expression via alternative transcription start sites (TSSs), increased sequence mutations, exon skipping, or through transient gene methylation.
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The enriched expressions of these molecules in response to visual inputs could cause or modulate plasticity in the primate V1.
Thus, lysosomal Ca 2+ signaling may modulate plasticity in the manner required at all stages of multiple membrane fusion events that are dependent on Ca 2+ for the effective formation of the SNARE complexes.
The interrelationship between plasticity and phasic activation of dopamine neurons and the relationship between phasic dopamine and plasticity in dopamine neurons that modulates plasticity in the LA remains to be determined.
This hormone is also produced in humans, suggesting that it could be manipulated to modulate plasticity of the adipose organ.
The fact that somatic spiking can modulate plasticity is well established by STDP experiments (spike timing-dependent plasticity).
Hence, by modulating HCN channels that help shape the post-hyperpolarization changes, the NO-cGMP pathway may play an important role in modulating synaptic plasticity in the DCN and thereby contribute to certain types of motor learning.
The concept of the meta-neuron is inspired by the role of astrocytes in modulating synaptic plasticity in biological neural networks.
Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons.
Due to a recent report about the relevance of MAPK/ERK and AKT signaling pathways in modulating hepatocyte plasticity in monolayer culture, and the observation of affected ERK and AKT phosphorylation upon FAK/Src inhibition, we intended to define the relevance of these pathways on caveolin-1 expression.
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