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Over-expression of Myc also affects DNA replication, modulating origin of replication activity and leading to replication stress and DNA damage [7].
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At present, we have no explanation for the fact that varying spatial frequency does modulate the spatial origin of a perceptual transition (our results), but does not modulate average dominance duration during continuous viewing of rival images.
In addition, we conducted parallel analyses of replication and nucleosome dynamics that revealed that chromatin structure at origins is modulated during origin activation.
In fact, particular dense packing of the DNA tertiary structure could account for deceleration of the replication rate and, therefore, modulate origin activity as well [27].
Our results also revealed that origin architecture was actively modulated during origin firing.
Hence, one could speculate E-cadherin levels might modulate the cell of origin of HCC that carry a β-catenin mutation.
Our work identifies a novel function for Tel1 in modulating the timing of origin firing specifically at telomeres.
Future studies should focus on the interplay between GCN5 and other HATs in modulating the activity of origins and the subsequent steps in DNA replication.
Because of the common embryologic origin, alteration of the many factors modulating the development of the alimentary and the respiratory tract often results in structural abnormalities involving the two systems.
The painting represents the peak of Whistler's radical method of modulating tones of single colors.
In addition, production by fibroblasts of chemokines may be variably modulated by cytokines, with differences being related to the origin of the fibroblasts [ 4- 8].
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