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We speculate that the lag time in Salmonella could be an attribute of Salmonella secreted effectors modulating members of the core response module.
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Transmembrane ancillary subunits include the MinK-related proteins (MiRPs) encoded by KCNE genes, which modulate members of most Kv α subunit subfamilies, and the putative 12-transmembrane domain KCR1 protein, which modulates hERG.
Because DLK1-MEG3 regulatisn is dependent on polycomb-containing complexes, we assessed whether miR-300 could modulate members of the polycomb complexes PRC1 and PRC2.
Our results have demonstrated that CA-4-P could differentially modulate members of the HIF-1 signal transduction pathway depending on the cell's oxygenation status.
However, there is indirect evidence showing that glucose entry into cells is modulated by members of the GLUT family in fish.
Mammalian ALP transcript expression is modulated by members of the mitogen-activated protein kinase (MAPK) family.
It is well known that lipid molecules modulate several members of the TRP family [25].
In addition, IGF-1's effects are modulated by members of the insulin-like growth factor binding proteins (IGFBP) [ 21].
KCNQ1 (also known as KV7.1 or KVLQT1) is a voltage-gated potassium channel modulated by members of the KCNE protein family.
This study showed that complex polyphenols in the context of a model system can modulate select members of the human gut microbiota, revealing novel targets potentially involved in polyphenol metabolism and/or resistant microbes to be further investigated for polyphenol metabolism or resistance mechanisms [ 31].
Cell death through apoptosis is known to occur through two primary pathways: an extrinsic pathway that involves death receptors, and an intrinsic pathway that is modulated by members of the Bcl-2 family [ 46], which consists of outer mitochondrial membrane components [ 47].
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